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Replacement Therapy of Alpha 1-antitrypsin Deficiency ...

There were no untoward side effects consequent to this approach to the replacement therapy of alpha 1-antitrypsin. These results demonstrate that the parenteral replacement of alpha 1-antitrypsin provides a means of obtaining elastase-antielastase balance within the lung of individuals with this serum protease inhibitor deficiency.

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Vitamin B12 Deficiency: Recognition and Management ...

Sep 15, 2017· Oral and injectable vitamin B 12 are effective means of replacement, but injectable therapy leads to more rapid improvement and should be considered in patients with severe deficiency …

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Replacement therapy for inherited enzyme deficiency ...

Background and methods: Gaucher's disease, the most prevalent of the sphingolipid storage disorders, is caused by a deficiency of the enzyme glucocerebrosidase (glucosylceramidase). Enzyme replacement was proposed as a therapeutic strategy for this disorder in 1966. To assess the clinical effectiveness of this approach, we infused macrophage-targeted human placental glucocerebrosidase (60 IU ...

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Treatments for Alpha-1 (Alpha-1 Antitrypsin Deficiency)

Augmentation Therapy. There's only one specific treatment to fight alpha 1: augmentation therapy. It's also called replacement therapy. It's been around for 25 years, but it's attracting more ...

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Replacement therapy for bleeding episodes in factor VII ...

One-day replacement therapy resulted in very favourable outcomes in haemarthroses, and was successful in muscle/subcutaneous haematomas, epistaxis and gum bleeding. For menorrhagia, single- or multiple-dose schedules led to favourable outcomes.

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FDA approves weekly therapy for adult growth hormone ...

Sep 01, 2020· [9/1/2020] The U.S. Food and Drug Administration approved Sogroya (somapacitan) on August 28 for adults with growth hormone deficiency. Sogroya is the first human growth hormone (hGH) therapy …

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Human Growth Hormone Replacement Therapy

Oct 15, 2015· HGH therapy is a prescription medication used to return the HGH levels in the blood to normal in patients whose bodies are not making enough growth hormone. HGH therapy is only available with a doctor's prescription. Human growth hormone replacement therapy is only given via injection. All HGH injections contain the prescription drug somatropin.

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Modern iron replacement therapy: clinical and ...

Dec 01, 2017· Iron deficiency, with or without anemia, is extremely frequent worldwide, representing a major public health problem. Iron replacement therapy dates back to the seventeenth century, and has progressed relatively slowly until recently. Both oral and intravenous traditional iron formulations are known to be far from ideal, mainly because of tolerability and safety issues, respectively. At the ...

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Plasminogen replacement therapy for the treatment of ...

Plasminogen replacement therapy should provide an effective treatment of the manifestations of congenital plasminogen deficiency. An open-label phase 2/3 study of human Glu-plasminogen administered IV at 6.6 mg/kg every 2 to 4 days in 15 patients with congenital plasminogen deficiency …

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UpToDate

Apr 05, 2021· Six weeks after treatment initiation, fatigue was improved in the IV iron arm (decrease of 1.1 versus 0.7 on a 10-point scale, from a baseline of 4.5 in both groups). The effect was more pronounced in those with a baseline serum ferritin ≤15 ng/dL. Benefits of iron supplementation persisted at …

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The single IGF-1 partial deficiency is responsible for ...

The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy. Olleros Santos-Ruiz M(1), Sádaba MC(2), Martín-Estal I(3), Muñoz U(2), Sebal Neira C(2), Castilla-Cortázar I(4). Author information: (1)Fundacion de …

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Global Hormone Replacement Therapy Market Size ...

Hormone replacement therapy refers to the treatment of the patients with hormone deficiency due to conditions such as dwarfism or women nearing menopause, which requires replacement of hormones in the body whose levels have become low. Market competition is intense. Eli Lilly, Pfizer, AbbVie, Novo ...

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Hormone Replacement Therapy (HRT) for Men | Low ...

Replacement Therapy for Low T. The ideal testosterone therapy maintains normal concentrations of the hormone without having significant side effects. Several kinds of hormone replacement are currently available at The Turek Clinic, including oral, injectable, transdermal and buccal mucosal systems as outlined in Table 2. Table 2.

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Systemic modified messenger RNA for replacement therapy in ...

Apr 27, 2020· Modified mRNA-based replacement therapy may also extend treatment to patients with non-severe mutations such as S or heterozygous Z alleles for whom pulmonary deficiency …

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Hormone Replacement Therapy for Women | Hormone Deficiency …

Hormone Replacement Therapy. Your body contains millions of hormone receptors. As we age, hormone production declines. The decline in our hormones is one of the leading causes of most diseases, including mood disorders and metabolic issues, …

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Oral Vitamin B12 Replacement for the Treatment of ...

Aug 23, 2016· Vitamin B12 deficiency is a common condition, and many are undiagnosed. ... It may be important to study the knowledge and practices of doctors/health-care workers with regard to oral replacement therapy with vitamin B12 for patients with pernicious anemia. Surveys on patients' preferences for oral or IM replacement would be informative to ...

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Congenital sucrase-isomaltase deficiency: diagnostic ...

Jul 10, 2020· Congenital sucrase-isomaltase (SI) deficiency is a rare genetic condition characterised by a deficiency in the brush-border SI enzyme, resulting in an inability to metabolise sucrose and starches. Six cases of congenital SI deficiency treated with Sucraid (sacrosidase, a yeast-derived enzyme that fa …

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What Are the Signs That You Need Hormone Replacement Therapy?

Jul 05, 2020· Signs of Hormone Deficiency in Men. Many male patients who pursue hormone replacement therapy find that, in the beginning, they're unsure of how to explain their hormone deficiency symptoms. However, men as young as 30 often begin to notice the impact that decreased testosterone levels has on their bodies and lifestyles. Andropause

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Increased prevalence of radiological spinal deformities in ...

Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy. Mazziotti G(1), Bianchi A, Bonadonna S, Nuzzo M, Cimino V, Fusco A, De Marinis L, Giustina A.

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The relationship between hormone replacement therapy and ...

May 02, 2018· Hormone replacement therapy also helps in weight management especially for older women. The bottom line is the benefits of hormone replacement therapy far outweigh the risks. If you suffer from iron deficiency anemia, you need to schedule a hormone test with a hormone therapy replacement center today. Article Submitted By Community Writer

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Replacement Therapy for Inherited Enzyme Deficiency ...

Replacement Therapy for Inherited Enzyme Deficiency — Macrophage-Targeted Glucocerebrosidase for Gaucher's Disease List of authors. Norman W. Barton, M.D., Ph.D.,

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An update on the use of immunoglobulin for the treatment ...

Immunoglobulin therapy in immune deficiencies. While there are well over 150 different forms of primary immunodeficiency diseases, about 70% of all patients have defects of antibody production, and thus immunoglobulin replacement therapy provides the first line of treatment for these subjects [].Antibody deficiencies can result from errors in B-cell differentiation at different stages of ...

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Erectile Dysfunction and Testosterone Replacement Therapy

Oct 22, 2019· Testosterone deficiency can be treated by: ... All men considering testosterone replacement therapy should undergo a thorough prostate cancer screening -- …

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AGH Replacement Therapy With mTBI - Full Text View ...

Apr 30, 2021· The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild traumatic brain injury (mTBI).

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Testosterone Deficiency Guideline - American Urological ...

Despite clinical experience that some men with testosterone deficiency and diabetes improve glycemic control with testosterone therapy, nine RCTs that assessed the impact of testosterone therapy on measures of diabetes demonstrated that there were no significant differences in HbA1c levels between those who were treated with testosterone and ...

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Growth hormone deficiency and replacement therapy in ...

Growth hormone deficiency and replacement therapy in adults: Impact on survival Christa C. van Bunderen1,2 & Daniel S. Olsson3,4 Accepted: 1 October 2020 # The Author(s) 2020 Abstract In a seminal paper from 1990, Rosen and Bengtsson suggested that hypopituitary patients with a …

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Bleeding Disorders | NHLBI, NIH

Factor replacement therapy is a type of treatment where clotting factors that are from blood donations or made in a lab are given to replace the missing clotting factor. Your doctor may recommend factor replacement therapy when you experience bleeding or to prevent bleeding from occurring.

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Testosterone Replacement Therapy: Myths and Facts

WebMD explains testosterone replacement therapy, including the types of treatment, the impact it has on low T, and the risks. ... "Testosterone Therapy in Adult Men with Androgen Deficiency ...

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Immunoglobulin Replacement Therapy for Immune Deficiency ...

Immunoglobulin Replacement Therapy for Immune Deficiency Immunoglobulin (IgG) replacement therapy is an innovative and successful therapy for people with immunodeficiency disorders. Immunodeficiency disorders weaken the immune system, allowing infections and other health problems to occur more easily.

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Iron Deficiency Anemia: Evaluation and Management

Jan 15, 2013· in pregnant women with iron deficiency anemia; how- ever, if the hemoglobin level does not increase by 1 g per dL (10 g per L) after one month of therapy in children

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Testosterone deficiency: Practical guidelines for ...

Testosterone deficiency in men is a common but often-missed diagnosis. After confirmation of the diagnosis, exclusion of any revers­ible causes, or contraindications to the use of testosterone, replacement therapy may be offered. Methods of replacement include injectable tes­tosterone esters, transdermal tes­tosterone (gels or patches), or ...

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Folate deficiency - Treatment algorithm | BMJ Best Practice US

Tests for vitamin B12 deficiency should be ordered, in addition to those for folate deficiency. Test results determine subsequent therapy. Folic acid replacement therapy should be instituted simultaneously to packed red blood cell transfusion in patients with severe anemia and symptoms of …

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Testosterone therapy: Potential benefits and risks as you ...

Apr 04, 2020· Hypogonadism hampers the ability to produce normal amounts of testosterone due to a problem with the testicles or with the pituitary gland that controls the testicles. Testosterone replacement therapy, in the form of injections, pellets, patches or gels, can improve the signs and symptoms of low testosterone in these men.

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New Paradigms and Therapies for Iron Replacement in Iron ...

Supporting this position is a 2014 paper by Gesquiere and colleagues in Obesity Surgery, which reported that more than 70% of bariatric surgery patients have iron deficiency anemia even after oral iron repletion. As a result, I use IV iron as frontline therapy for all patients after bariatric surgery.

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Iron Deficiency Anemia: Evaluation and Management ...

Jan 15, 2013· Iron deficiency anemia is diminished red blood cell production due to low iron stores in the body. It is the most common nutritional disorder worldwide and accounts for approximately one-half of ...

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Replacement therapy for congenital Factor X deficiency.

Replacement therapy for congenital Factor X deficiency. Knight RD, Barr CF, Alving BM. We studied a young woman with severe (less than 1%) congenital factor X deficiency during a 2-year period in order to document the levels of factor X required to provide hemostasis for vaginal bleeding, epistaxis, and hemarthroses, as well as during surgery.

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A Review on Vitamin D Deficiency Treatment in Pediatric ...

Oct 03, 2016· Patients diagnosed with AED-induced osteoporosis may need larger doses of vitamin D replacement therapy to correct biochemical abnormalities (PTH, calcium, and phosphorus). 18 Calcidiol concentrations should be monitored (prior to or at the start of AED initiation) and then yearly thereafter. If diagnosed with vitamin D deficiency, initiating ...

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Immunoglobulin Replacement Therapy | Choosing Wisely

Immunoglobulin replacement (IgG) therapy can help people with immunodeficiency disease. Others get IgG even though they don't need it. That's not a good idea. Some people have frequent, severe infections because their bodies don't make enough antibodies. Antibodies are proteins that the body produces to fight off harmful substances.

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